Arih1是什么
Web19 set 2024 · Because the main known regulators of mitophagy are frequently inactivated in cancer cells, the mechanisms that regulate mitophagy in cancer cells are not fully understood. Here, we identified an E3 ubiquitin ligase (ARIH1/HHARI) that triggers mitophagy in cancer cells in a PINK1-dependent manner. We found that ARIH1/HHARI … WebARIH1 Expression Promotes Elimination of Depolarized Mitochondria Parkin is a member of the RBR family of E3 ligases that is composed of 14 complex multidomain enzymes. As it is frequently downregulated in cancer cells, we investigated whether other E3 ligases could control mitophagy in these cells.
Arih1是什么
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Web20 apr 2024 · Overexpression of ARIH1 suppresses tumor growth and promotes cytotoxic T cell activation in wild-type, but not in immunocompromised mice, highlighting the role of ARIH1 in anti-tumor immunity. Web25 ago 2016 · Abstract. Hundreds of human cullin-RING E3 ligases (CRLs) modify thousands of proteins with ubiquitin (UB) to achieve vast regulation. Current dogma posits that CRLs first catalyze UB transfer from an E2 to their client substrates and subsequent polyubiquitylation from various linkage-specific E2s. We report an alternative E3-E3 …
WebARIH1 Gene, Drug Resistance, Tissue Distribution, Mutation Distribution, Variants, ARIH1 Genome Browser, ARIH1 References. ARIH1 - Explore an overview of ARIH1, with a histogram displaying coding mutations, full tabulated details of all associated variants, tissue distribution and any drug resistance data. Web21 apr 2024 · 示意图：EGFR-GSK3α-ARIH1信号通路调控PD-L1的蛋白酶体降解 4T1是一种小鼠乳腺癌细胞，实验表明，ARIH1过表达的4T1细胞接种至免疫系统缺陷的裸鼠体内 …
Web5 mar 2024 · ARIH1 ariadne RBR E3 ubiquitin protein ligase 1. ARIH1. ariadne RBR E3 ubiquitin protein ligase 1. Gene ID: 25820, updated on 5-Mar-2024. Gene type: protein coding. Also known as: ARI; HARI; HHARI; UBCH7BP. See all available tests in GTR for this gene. Go to complete Gene record for ARIH1. Go to Variation Viewer for ARIH1 … Web27 apr 2024 · 该研究筛选到了一系列能降低pd-l1膜蛋白水平的先导化合物，鉴定了pd-l1蛋白新的e3泛素连接酶arih1，揭示了egfr-gsk3α-arih1通路调控肿瘤免疫的新机制，提示 arih1 有望成为肿瘤免疫治疗的新靶点。 夏宏光 团队长期致力于靶向蛋白降解的机制研究和药物开发。
Web31 gen 2024 · hnRNP E1 is a candidate substrate for ARIH1. Previous research has demonstrated that hnRNP E1 plays an important role in EMT induction and tumor progression in breast cancer. hnRNP E1 mRNA is ubiquitously expressed across multiple cell types, however, little is known about how this RNA binding protein is regulated post …
• Aguilera M, Oliveros M, Martínez-Padrón M, Barbas JA, Ferrús A (2000). "Ariadne-1: a vital Drosophila gene is required in development and defines a new conserved family of ring-finger proteins". Genetics. 155 (3): 1231–44. doi:10.1093/genetics/155.3.1231. PMC 1461160. PMID 10880484. • Zhang Y, Redina O, Altshuller YM, Yamazaki M, Ramos J, Chneiweiss H, Kanaho Y, Frohman MA (2001). "Regulation of expression of phospholipase D1 and D2 by PEA-15, … • Aguilera M, Oliveros M, Martínez-Padrón M, Barbas JA, Ferrús A (2000). "Ariadne-1: a vital Drosophila gene is required in development and defines a new conserved family of ring-finger proteins". Genetics. 155 (3): 1231–44. doi:10.1093/genetics/155.3.1231. PMC 1461160. PMID 10880484. • Zhang Y, Redina O, Altshuller YM, Yamazaki M, Ramos J, Chneiweiss H, Kanaho Y, Frohman MA (2001). "Regulation of expression of phospholipase D1 and D2 by PEA-15, a nove… osteology suppliesWebARIH1 INFORMATION. Proteini. Full gene name according to HGNC. Ariadne RBR E3 ubiquitin protein ligase 1. Gene namei. Official gene symbol, which is typically a short … osteo lower plentyWebAriadne RBRE3泛素蛋白连接酶1 (ARIH1，也称为HHARI)是一种RING-between-RING (RBR)型泛素E3连接酶，与两种E2泛素结合酶UBCH7和UBCH842结合。 最近的结构分 … osteolysis hip icd 10Web30 nov 2024 · Aarch64是ISA（Instruction Set Architecture） 中对ARMv8-A中引入的64位架构定义的名称，而ARM则是对于「RISC指令集架构处理器」的大众读法。 在目前来看它们都指的同一事物，也就是公版64位ARMv8以后的所有64位ARM架构。而据我所知在Linux平台上一般都是采用aarch64命名，比如说Android： osteology schoolsWeb10 ott 2024 · ARIH1 is a component of the CRL system and regulates cancer progression and xenophagy of cytosolic bacteria 46, 49, 50, 51. Since ARIH1 interacts with cGAS … osteo longny au percheWeb23 apr 2024 · We further show that rare variants in the human homolog of ari-1 (ARIH1) are associated with thoracic aortic aneurysms and dissections, conditions resulting from smooth muscle cell (SMC) dysfunction. Human ARIH1 rescues fly ari-1 mutant phenotypes, whereas human variants found in patients fail to do so. In addition, SMCs obtained from patients ... osteolysis medicalWebarXiv网站简介. arXiv是一个收集物理学、数学、计算机科学、生物学与数理经济学的论文预印本的网站。. 其中arXiv发音同“archive”，因为“X”代表希腊字母 \chi ，国际音标为 [kai] … osteolysis of prosthetic joint implant