Cisplatin toxicity review

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August undefined, 2024

WebDec 12, 2024 · This systematic review underlines some practice principles for cisplatin-induced nephrotoxicity. Therefore, at a cisplatin dosage of less than 50 mg/m 2, both short-duration and low volume hydration with normal saline prevent nephrotoxicity, as well as outpatient administration. WebReview on Pharmacology of Cisplatin: Clinical Use, Toxicity and Mechanism of Resistance of Cisplatin Sara A. Aldossary Clinical pharmacy college, king faisal university Alhassa …

Genetic Variations and Cisplatin Nephrotoxicity: A Systematic Review

WebApr 5, 2024 · Concurrent chemoradiotherapy with 3-weekly cisplatin 100 mg/m 2 has been the standard of care for locoregionally advanced head and neck cancer (LA-HNC) with level I evidence. While the outcomes in terms of efficacy have been well established, the toxicity profile, compliance, and real-world applicability has been an area of ongoing concern for … WebCisplatin-induced kidney toxicity is reviewed here. The use of cisplatin in patients with pre-existing kidney dysfunction and the kidney effects of the platinum analogs, … how far is savannah from bluffton sc

Toxicity, risk factors and management of cisplatin-induced toxicity: …

WebSep 21, 2016 · Cisplatin produced superior response rates and survival in head and neck cancers. There are no published randomized phase III studies of bladder, cervical, endometrial, and esophageal cancers. CONCLUSION: Carboplatin does not possess equivalent activity to cisplatin in all platinum-sensitive tumors. WebAug 5, 2024 · Cisplatin is an FDA approved anti-cancer drug that is widely used for the treatment of a variety of solid tumors. However, the severe adverse effects of cisplatin, particularly kidney toxicity, restrict its clinical and medication applications. The major mechanisms of cisplatin-induced renal toxicit … WebOct 7, 2024 · Cisplatin is one of the most widely used chemotherapeutic drugs in the treatment of a wide range of pediatric and adult malignances. However, it has various side effects which limit its use. Cisplatin mouse models are widely used in studies investigating cisplatin therapeutic and toxic effects. how far is savannah ga from myrtle beach sc

Chemoradiotherapy with paclitaxel liposome plus cisplatin for …

Clinical comparative investigation of efficacy and toxicity of ...

WebCisplatin, an effective antineoplastic drug used in the treatment of many cancers, has ototoxic potential, thus placing cancer patients, receiving this treatment, at risk of hearing loss. WebFeb 22, 2024 · Cisplatin is a known nephrotoxic agent, so reducing its concentration to get a similar toxicity profile in NSCLC cells is advantageous. For the two normal lung cell lines ( Figure 4 A,B), while the Lipo-PEITC-CDDP caused the lowest survival percentages, 59.0 ± 15.7% and 71.5 ± 11.0% for WI-38 and BEAS-2B, respectively, the cytotoxic effect of ... how far is savannah georgia from tallahasseeWebMethods: This article examined a collection of studies suggesting that CYP450 enzymes may influence cisplatin toxicity. We performed a narrative mini-review. Results: The studies review showed that CYP450 enzymes have an important role in drug-induced hepatotoxicity and nephrotoxicity, mainly CYP2E1 and CYP4A11. how far is savannah ga to morristown tn

"WebOct 5, 2014 · Furthermore, combination therapies of cisplatin with other drugs have been highly considered to overcome drug-resistance and reduce toxicity. This comprehensive review highlights the physicochemical properties of cisplatin and related platinum-based drugs, and discusses its uses (either alone or in combination with other drugs) for the ... " - Cisplatin toxicity review

Cisplatin toxicity review

WebThis systematic review and meta-analysis investigates 4 studies for the association of sodium thiosulfate with reduced risk of ototoxic effects among patients t ... A, Guerrero-Avendaño G, Zapata-Tarrés M, Medina-Sansón A. Toxicity prevention with amifostine in pediatric osteosarcoma patients treated with cisplatin and ... WebApr 5, 2024 · Cisplatin has been on the market for 38 years, and yet we are still struggling with its major side effect of nephrotoxicity. Many nephro-protective measures have been studied. In this review, we discuss the …

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WebSep 18, 2024 · Toxicity CIsplatin has several black box warnings, including nephrotoxicity, peripheral neuropathy, severe nausea and vomiting, and myelosupression. Gastrointestinal toxicity - Nausea and vomiting are dose-related side effects that can be severe and lead to metabolic derangements; this can persist for up to 1 week after administration. WebThe RRs were 22% and 22%, respectively. One-year survival rates were 31% and 36%, respectively. What we have researched was Abraxane plus cisplatin and gemcitabine plus cisplatin, and their RRs were higher than ECOG 1594 clinical trials. The RR between the TP group and GP group also had significant difference.

WebDec 1, 2024 · Dose adjustments for both docetaxel and cisplatin were performed according to pre-defined criteria for each type of toxicity (mainly grade 4 neutropenia and grade 3–4 neuropathy). Two dose reductions were allowed for DC75 (first to 60 mg/m 2, second to 50 mg/m 2), but only 1 reduction was allowed for DC60 and DCM therapy (to 50 mg/m 2). … WebSep 15, 2024 · Cisplatin is mutagenic, teratogenic and carcinogenic and its use has been show to increase the risk of secondary malignancies, particularly leukemia. …

WebMar 13, 2024 · Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the … WebMar 15, 2024 · Cisplatin is a bedrock of cancer management and one of the most used chemotherapeutic agents in the treatment of germ cell, lung, bladder, ovarian, and head and neck cancers. Approximately 500,000 ... This is a review of cisplatin-induced ototoxicity and strategies to minimize the negative impact on QoL and outcome.

WebNov 12, 2024 · Commonly reported side effects of cisplatin include: bone marrow depression, nephrotoxicity, and ototoxicity. Continue reading for a comprehensive list of …

WebSep 15, 2024 · SIDE EFFECTS. Nephrotoxicity - Dose-related and cumulative renal insufficiency is the major dose-limiting toxicity of cis-platin.Renal toxicity has been … high capacity biochar processorWebCisplatin is a platinum-based chemotherapeutic that has long since been effective against a variety of solid-cancers, substantially improving the five-year survival rates for cancer patients. Its use has also historically been limited by its adverse drug reactions, or cisplatin-induced toxicities (CITs). Of these reactions, cisplatin-induced nephrotoxicity (CIN), … high capacity bluetooth mp3 playerWebOct 5, 2014 · In clinical trials, cisplatin is often selected due to its strong antitumor activity, but its adverse effects include renal toxicity (Iwasaki, Nagata et al., 2005), nausea and … high capacity backboneWebCisplatin is a widely used and highly effective cancer chemotherapeutic agent. One of the limiting side effects of cisplatin use is nephrotoxicity. Research over the past 10 years has uncovered many of the cellular mechanisms which … how far is savannah georgia to tybee islandWebSep 27, 2024 · We conducted a systematic review to identify which genetic variants consistently associated with cisplatin-induced nephrotoxicity in oncology patients and assessed whether there are genetic variants that might be clinically relevant to guide cisplatin treatment. Methods how far is savannah from newnan gaWebMar 2, 2024 · After several decades, cisplatin continues to be an essential drug for the treatment of several tumors, however, its potential nephrotoxicity is still a clinically … how far is savannah ga from columbus ohWebSep 20, 2024 · The incidence of hearing loss was lower in the sodium thiosulfate and cisplatin arm (39%) compared with the cisplatin alone arm (68%); unadjusted relative … high capacity blank cd