WebJul 1, 2007 · Connective tissue growth factor (CCN2) is a profibrotic factor acting downstream and independently of TGF-β to mediate renal fibrosis. Although inflammation is often involved in the initiation and/or progression of fibrosis, the role of inflammatory cytokines in regulation of glomerular CCN2 expression, cellular proliferation, and … WebNov 1, 2024 · In this study, we investigated the effect of treprostinil on cAMP activation and on PDGF-BB induced remodelling parameters, which included the secretion of TGF-β1, connective tissue growth factor (CTGF), PASMC proliferation and deposition of collagen type I, collagen type IV and fibronectin. All experiments were performed in isolated …
Essential role of connective tissue growth factor (CTGF) in
WebThe plasma concentrations of adiponectin, TGF-β1, CTGF, IL-6, and TNF-a, or cell culture supernatant concentrations of FN, and MMP-1 were quantitated by ELISA, using assay kits (Sangon biotech, Shanghai, China) in accordance with the manufacturer’s instructions, collagen I ELISA Kit was from MSK Biotechnology Company (Wuhan, China). WebSep 17, 2024 · The activity of AR, a member of the nuclear receptor superfamily, is dependent on androgen-independent activation in the etiopathogenesis of DIGO. 9, 10 AR upregulates CTGF (CCN2) and procollagen α1(I) messenger ribonucleic acid (mRNA) expression and can induce the accumulation of the extracellular collagen matrix as well … easton \u0026 easton llp
Adiponectin and inflammatory factors in keloid JIR
WebJul 1, 2007 · Connective tissue growth factor (CCN2) is a profibrotic factor acting downstream and independently of TGF-β to mediate renal fibrosis. Although … WebTransforming growth factor-beta 1 (TGF-beta 1), which appears in high concentrations in fibrotic cardiac tissue, is a potent inductor of tissue collagen deposition and of the … WebReduced production of type I procollagen is a prominent feature of chronologically-aged human skin. Connective tissue growth factor (CTGF/CCN2), a downstream target of the transforming growth factor-β (TGF-β)/Smad pathway, is highly expressed in numerous fibrotic disorders, where it is believed to stimulate excessive collagen production. culvert headwall vs wingwall