Daptomycin and myopathy
WebApr 2, 2024 · Vancomycin (VCM) and daptomycin (DAP) are standard therapies for methicillin-resistant Staphylococcus aureus (MRSA) bacteremia, despite concerns regarding clinical utility and growing resistance. WebApr 1, 2005 · We conclude that daptomycin was the likely cause of our patient's myopathy and possible hepatotoxicity. To our knowledge, this is the only case of daptomycin myopathy with associated liver function abnormalities.
Daptomycin and myopathy
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WebMar 7, 2024 · INTRODUCTION. Daptomycin is a lipopeptide antimicrobial with activity against gram-positive organisms, including antimicrobial-resistant pathogens such as methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus spp … WebDaptomycin is given parenterally once a day. Over 90% is bound to serum protein. Dosing is adjusted for renal failure. Because daptomycin can cause reversible skeletal …
WebJun 15, 2006 · Given the temporal relationship between daptomycin initiation and elevation in CPK level, daptomycin was identified as the offending agent and was … WebJun 6, 2024 · Daptomycin 500mg Powder for Solution for Injection/ Infusion Active Ingredient: daptomycin Company: Panpharma UK Ltd See contact details ATC code: J01XX09 About Medicine Prescription only medicine Healthcare Professionals (SmPC) Patient Leaflet (PIL) This information is for use by healthcare professionals Last updated …
WebSep 1, 2006 · This article will: 1) review the mechanism of myopathy induction by daptomycin; 2) review the literature reports of myopathy associated with … WebDec 19, 2024 · Daptomycin has been associated with clinical myopathy in 2% to 14% of patients. Similarly, statins are associated with myopathy in 5% to 10% of patients. …
WebDaptomycin is a lipopeptide antibacterial with a spectrum of activity similar to vancomycin but its efficacy against enterococci has not been established. It needs to be given with …
WebMar 15, 2013 · We retrospectively evaluated the effectiveness and safety of high-dose daptomycin (HD-daptomycin) therapy (>6 mg/kg) in a multicenter cohort of adult patients with enterococcal infections to describe the characteristics and outcomes. Two hundred forty-five patients were evaluated. cry talkingWebDaptomycin is given parenterally once a day. Over 90% is bound to serum protein. Dosing is adjusted for renal failure. Because daptomycin can cause reversible skeletal … crytal missWebDaptomycin has excellent coverage against gram-positive bacteria. The adverse effect profile has included rare reports of myopathy and elevated CK levels. Daptomycin is a … dynamics great plains tablesWebMar 10, 2024 · Myopathy, defined as muscle aching or muscle weakness, in conjunction with increased serum CK concentrations up to 10 times ULN reported in patients … crytal nail file with holderWebDaptomycin myopathy might be dose or frequency related. In phase 1 trials, two out of five patients developed clinically significant myopathy with myalgias and CK elevation when used at 4 mg/kg/q12 hours . This happened less frequently in further studies using a 4 mg/kg/q24 hours dosage. Of 534 patients in a study receiving daptomycin, only 11 ... dynamics great plains jobsWebManufacturer advises monitor plasma creatine phosphokinase (CPK) before treatment and then at least weekly during treatment; monitor CPK more frequently in patients at higher risk of developing myopathy, including those with renal impairment, taking other drugs associated with myopathy, or if CPK elevated more than 5 times upper limit of normal … dynamics great plains loginWebDaptomycin is a canonical antibiotic used very commonly in practice for its bactericidal activity against Gram-positive bacteria, including vancomycin-resistant enterococci … crytal presthetic designer