WebFeb 1, 2024 · In contrast, high SMARCA2 expression was associated with good prognosis. We compared tumors with high versus low expression of SMARCA4 or SMARCA2 in LIHC and KIRC cohorts from The Cancer Genome Atlas. WebDegron mediated BRM/SMARCA2 depletion uncovers novel combination partners for treatment of BRG1/SMARCA4-mutant cancers. ... screen and discovered a combinatorial effect between BRM depletion and the knockout of various genes of the oxidative phosphorylation pathway and the anti-apoptotic gene MCL1. Together these studies …
Degron mediated BRM/SMARCA2 depletion uncovers novel
WebJan 24, 2024 · Reversible protein phosphorylation plays a critical role in the regulation of various cellular processes, including intracellular signaling and protein–protein interaction. ... SMARCA2 has been shown to be an essential gene in SMARCA4-related cancer cell lines. Thus, SMARCA2 may be targeted in SMARCA4-related or -deficient cancers. However ... WebDec 7, 2024 · SMARCA2, an evolutionarily conserved catalytic ATPase subunit of SWI/SNF complexes, has been implicated in development and diseases; however, its role in … citreon arnold clark sighthill
ARI1A Antibody Affinity Biosciences LTD 亲科生物官网
WebSMARCA2 Is a Novel Interactor of NSD2 and Regulates Prometastatic PTP4A3 through Chromatin Remodeling in t(4;14) Multiple Myeloma. Two cases of Nicolaides-Baraitser … WebFeb 12, 2024 · SMARCA4-DTS has poor prognosis, with a median survival of 7 months [ 7 ]. Therefore, the development of effective treatments is urgently needed. A SMARCA4 mutant lung cancer cell line was recently reported to show oxidative phosphorylation (oxphos) activity and sensitivity to its inhibitor, IACS-010759 [ 13 ]. WebMar 21, 2024 · SMARCA2 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 2) is a Protein Coding gene. Diseases associated with … citreon showroom in mumbai